Multicenter randomized clinical trial of donepezil for memory impairment in multiple sclerosis

Krupp et al. Neurology. 2011 Apr 26;76(17):1500-7.

The aim of this study was to determine if memory could be improved by donepezil, the drug licensed for memory impairment in Alzheimer’s disease, in PwMS. Unfortunately, Donepezil did not improve memory as compared to placebo.

“Memory impairment in MS is one of the hidden disabilities and clearly a difficult one to treat. A further argument to prevent damage rather than to try and treat it.”

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