Audoin et al. J Neurol Neurosurg Psychiatry. 2010 Jun;81(6):690-5. Epub 2010 Apr 14.
The present study performed on a large group of CIS patients demonstrated that regional grey matter atrophy is present right after the first clinical event of multiple sclerosis and mainly affects the deep grey matter.
“This and other studies show that grey matter involvement is there from the start. I use this as argument for aggressive early treatment. It is better to protect the brain, particularly the grey matter, than to compensate for the damage or to try an restore its function in the future. At the moment we have no restorative therapies that have been shown to work.”
One thought on “Grey Matter (3) – Atrophy mainly affects the limbic system and the deep grey matter at the first stage of MS”
Aggressive early treatment may be suitable for RRMS patients but the bane of this notion is that PPMS patients wait months, if not many years, before seeking medical help because they do not suffer from attacks and instead slowly worsen. When you consider that 85% of PwMS have RRMS aggressive treatment makes sense.There may not be current therapies that have restorative potential but there’s lots going on (see Anna Williams research in Remyelination in Multiple Sclerosis: http://www.crm.ed.ac.uk/research/group/remyelination-multiple-sclerosis).