Study objective: To determine if chronic cerebral venous insufficiency (CCSVI) exists in MS’ers using the criteria proposed by Zamboni.
Study design: MS’ers and people with clinically isolated syndrome were matched by age and sex with subjects with migraine or no neurological disease.
Main study outcome measures: Five parameters of venous outflow used by Zamboni were examined.
Results: There was no significant difference in the number and type of venous outflow abnormalities in MS’ers compared with controls.
Conclusion: This study does not support the theory that CCSVI exists in MS.
Epub ahead of print: Marder et al. No Cerebral or Cervical Venous Insufficiency in US Veterans With Multiple Sclerosis. Arch Neurol. 2011 Aug 8.
“Another negative, independent, study makes it unlikely that CCSVI is going to fulfill Bradford-Hill’s criteria for causation or the clinicopathological entity to be considered a diease.”
Other posts on this blog of relevance:
15 Apr 2011
CCSVI – time for Sir Bradford-Hill’s criteria for causation. Did you know that there is a whole science behind causation? It started way back in the later 1800’s when Robert Koch formulated his postulates to persuade his …
29 Jul 2011
The scientific framework on which we should be holding this debate is around Bradford-Hill’s criteria for causation. Please see my previous post on this issue: …
28 Jul 2011
Please read post on this blog on the Bradford-Hill criteria of causation and “Bad Science” by Ben Goldacre. Two deaths, two unnecessary deaths, should never have occurred. They unfortunately occurred outside of ethically …