Another vitamin D update

Epub ahead of printHollis BW. Short-term and long-term consequences and concerns regarding valid assessment of vitamin D deficiency: comparison of recent food supplementation and clinical guidance reports. Curr Opin Clin Nutr Metab Care. 2011 Sep 19.

Purpose of review: The function and use of vitamin D supplementation has become very controversial. This review attempts to provide a balanced perspective with respect to the experimental findings published in the past 18 months.

Recent findings: The recent contrasts between the Institute of Medicine (IOM) report and the Endocrine Societies report have caused great confusion with respect to the dietary requirement for vitamin D as well as the amount of circulating 25-hydroxyvitamin D that is desirable. Much recent data contradict the suggestions of the IOM report with respect to vitamin D’s role in chronic disease such as cancer, cardiovascular function, immune function and autoimmune ailments such as multiple sclerosis.
Summary: Controversy regarding supplementation with vitamin D is fueled by the different purposes of the IOM (guidance for food fortification and not to individualized patient care) and the Endocrine Societies (patient care) reports. Healthcare providers should formulate their own opinions with respect to vitamin D as it pertains to the care of their patient.
“Bruce Hollis the vitamin D sage has obviously written this review to address the discordant advice regarding levels of vitamin D supplementation for food fortification (public health) and clinicians (patient care). The bottom line is you need to be vitamin D replete and in the UK this requires a daily requirement of ~10,000U per day over the year (5,000 from diet and sunshine and 5,000 from supplements).”

“If you are new to this blog please check-out some of the previous posts on this blog that relate to vitamin D in MS. It is clear that this is a big issue for MS’ers.”

05 Jul 2011
“We know from numerous other studies that being deficient in vitamin D affects your immunity and increases your risk of infections and probably relapses.” “This study is another reason to make sure that you are vitamin D 

05 Jul 2011
We need sufficient amount of sunlight exposure to synthesis our body’s requirement of vitamin D; this does not happen in Britain and many parts of the world. Change in behaviours is contributing to vitamin D deficiency: 

28 Jul 2011

This allowed these investigators to study the association of maternal milk intake, maternal dietary vitamin D intake, and predicted maternal serum vitamin D during pregnancy and their daughters’ risk of developing MS. 

17 Jul 2011
In Australia and New Zealand, the number of people with vitamin D deficiency varies, but is acknowledged to be much higher than previously thought. One study found marginal deficiency in 23% of women, and another frank 

10 Aug 2011
Sunlight, vitamin D and cod liver oil and their impact on disease progression. Epub ahead of print: McDowell et al. Sun Exposure, Vitamin D Intake and Progression to Disability among Veterans with Progressive Multiple 

16 Jul 2011
The Endocrine Society’s guidelines, call people with levels under 50 nmol/L “vitamin-D deficient”, and those with levels between 50 nmol/L and 72.5 nmol/L “insufficient”. The society’s guidelines also offer an ‘ideal’ level of 

11 Jul 2011
“This study provides a hint that vitamin D supplementation that results in higher blood vitamin D levels many suppress EBV within the body. Interesting? We think very interesting and trying to work out how EBV and vitamin D 

10 Jul 2011
This study compared vitamin D status in 200, free-living, woman, aged between 20 to 55 years, from Tehran, a high-polluted area, and Ghazvin, a low-polluted area. Level of UVB (ultra-violet B – the part of the light spectrum 

28 Jun 2011
The active metabolite of vitamin D is a potent modulator of immune cells. In this study the investigators’ determined whether vitamin D, a sun-dependent nutrient can affect the cells athat are associated with the immune 

05 Jul 2011
Vitamin D websites. You may find these websites helpful: Vitamin D Council & Vitamin D3 World CoI: Nil. Posted by Gavin Giovannoni at 17:38 · Email This BlogThis! Share to Twitter Share to Facebook

20 Jun 2011
Previous studies have shown that serum vitamin D levels are genetically influenced. Therefore variations or polymorphisms in vitamin D pathway genes are candidates for association with MS susceptibility.Surprisingly, no 

01 Jun 2011
Small clinical studies of vitamin D supplementation in patients with MS have reported positive immunomodulatory effects, reduced relapse rates and a reduction in the number of gadolinium-enhancing lesions on MRI. 

17 Jul 2011
This study compared the relative potencies of vitamins D2 and D3 by giving a single dose of 50000 IU of the respective vitamins to 20 healthy male volunteers and followed the time course of blood vitamin D aover a period of 

07 Jul 2011
Sunlight, Vitamin D and EBV. More about the environmental risk factors that increase susceptibility to MS. “What we now need is a study to integrate these risk factors. Would you be interested in participating?” Posted by Gavin 

03 May 2011
Vitamin D Supplement Doses and Serum 25-Hydroxyvitamin D in the Range Associated with Cancer Prevention. How safe are high dose Vitamin D3 (vD3) supplements? In this study on over 3600 study participants ~25% of 

09 Jul 2011
Additional vitamin D-sensitive diseases such as Alzheimer’s disease, falls, meningitis, Parkinson’s disease, maternal sepsis, maternal hypertension (pre-eclampsia) and multiple sclerosis only account for 2-3% of global death. 

11 Apr 2011
Can vitamin D(3) supplementation prevent bone loss in persons with MS? A placebo-controlled trial. Osteoporosis (thinning of the bones) is common in MS. In this small study the investigators failed to show that a weekly dose 

24 Jul 2011
EBV viral load was lower at higher serum vitamin D concentrations in controls subjects. Conclusion: Past infection with EBV, but not current EBV viral load in whole blood, is significantly associated with increased CIS risk. 

03 Aug 2011
Vitamin D Deficiency and Latitude and Month of Birth. These are probably linked to sunshine which makes Vitamin D in humans. You get less  This lack of vitamin D may shape how your immune system develops. This may 

20 Dec 2010
THE AUTHORS’ CONCLUSIONS ARE SELF-EXPLANATORY: “The current level of evidence for the effectiveness of vitamin D supplementation in the management of people with MS is based on a single randomised control trial with 

07 Feb 2010
After our MS Research Day on the 30th January we have been asked by several people about the correct dose of vitamin D to take to try and prevent MS and related disorders. Unfortunately we don’t know. 

03 Dec 2010
The committee of scientists, convened by the National Academies’ Institute of Medicine, doubled the upper level of vitamin D that people that people between the ages of 9 and 50 can safely take in any given day from 2000 

24 Aug 2010
New research shows the effect of vitamin D on the genome is widespread and localises to genes and areas of the genome associated with increased susceptibility to MS and other autoimmune diseases. 

23 Mar 2010
This study adds compelling evidence in support of a role for vitamin D in reducing MS relapse rates as initially seen in smaller studies in adult MS cohorts (Wingerchuk et al, JNNP 2005; Soilu-Hänninen et al, JNNP, 2008). 

26 Jul 2010
Vitamin D is crucial for maintenance of the immune system and vD deficiency has been implicated in the causal pathway of MS. In this study genetic variants at three places in the genome were associated with vD levels. 

25 Aug 2011
Is it a co-incidence that Dr Ruth (Not Westheimer) is next to Dr VD (that’s Vitamin D not VD). P.S. If you are a Nutter, Anti-Vivisectionist (non-nutter AV’s are OK……we can have a conversation), then Don’t Do Your 

31 Mar 2010
Top up Vitamin D in the sun or pop a supplement, say researchers. Click here. Posted by Gavin Giovannoni at 19:07 · Email This BlogThis! Share to Twitter Share to Facebook Share to Google Buzz 

25 Apr 2010
We also make less vitamin D as our body stores D3 and has met it’s daily requirement. You cannot overdose on Vitamin D3 from sun exposure as unabsorbed D3 is processed on into supra sterols the body doesn’t use. 

14 Jun 2011
The current hypothesis is that if your mother was pregnant during winter ( and you were born in April), a time when she is more likely to be vitamin D deficient, it affected the development of your immune system making you 

19 Apr 2011
The effect of UVB on generating vitamin D seems the most likely candidate for explaining its relationship with MS. There is a pressing need to investigate the role of vitamin D and EBV and how they might interact to influence MS risk to 

09 Aug 2010
It’s discusses the virtues of Vitamin D, particularly where Britain’s health is concerned. The presenter interviews many leading experts in vitamin D such as Prof. Reinhold Vieth (University of Toronto), Dr. Doug Brown (MS Society) plus 

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