Probiotics work in EAE

Takata et al. The Lactic Acid Bacterium Pediococcus acidilactici Suppresses Autoimmune Encephalomyelitis by Inducing IL-10-Producing Regulatory T Cells. PLoS One. 2011;6(11):e27644.

BACKGROUND: Certain intestinal microflora are thought to regulate the systemic immune response. Lactic acid bacteria are one of the most studied bacteria in terms of their beneficial effects on health and autoimmune diseases; one of which is MS. They investigated whether the lactic acid bacterium Pediococcus acidilactici, which comprises human commensal bacteria, has beneficial effects on experimental autoimmune encephalomyelitis (EAE), an animal model of MS.

METHODS & RESULTS: P. acidilactici R037 was orally administered to EAE mice to investigate the effects of R037. R037 treatment suppressed clinical EAE severity as prophylaxis and therapy.

CONCLUSIONS: An orally administered single strain of P. acidilactici R037 ameliorates EAE by inducing regulatory cells. Their findings indicate the therapeutic potential of the oral administration of R037 for treating MS.

“Interesting study; I wonder if the same effects will be seen in humans. Can you imagine the nutriceutical industry getting involved with this? Danone or Nestle sponsor lactobacillus trial in MS!!”

4 thoughts on “Probiotics work in EAE”

  1. I take 9bn active cultures a day ( 3 pills of 3bn) following Ashton Embry's recommendation.unlike other supplements, I see zero downside risk with probiotics – as such very comfortable taking high doses regularly.What do you think G ?

  2. Re: "What do you think G ?"I wouldn't recommend it without more data. The only way to get data is to do a clinical trial. Just because something is perceived to harmless doesn't mean it is; there have been too many examples in the past for me to remain sceptical.

  3. I think we should put this mousey report into some perspective. The effect of this treatment was pretty small and although it reduced the severity of the disease abit, it did not stop the mice getting disease, so 100% of mice got the MS-like disease whilst on treatment. If we had used a pharmaceutical treatment such as Gilenya in the same testing situation, it would have resulted in the complete elimination of disease development (i.e. 0% of animals getting disease).As with many of the nutriceutical supplements there is no evidence-base for their use and the downrisk risk…. is putting a further hole in your pocket buying these products.

  4. It must be difficult to justify giving one set of patients the proposed drug and another just the placebo when you know they are receiving nothing and the only benefit they will get is the placebo effect, whilst there are DMT's that could help them already on the market. It's the greater good in the long run I suppose. I think I prefer the trials which are up against already available treatments- it sems more fair in a way.

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