Antibody response to EBV in MSers is elevated

Epub: Lindsey et al. The antibody response to Epstein-Barr virions is altered in multiple sclerosis. J Neuroimmunol. 2012 Sep 28.

Infection with Epstein-Barr virus (EBV) is associated with MS, and MSers have an increased antibody response to some EBV antigens. The major antigens of EBV are only partly defined. The hypothesis that was testes is that the antibody response to EBV is altered in MS. With ELISA, they found that antibodies to EB virions were increased in both serum and CSF of MSers. Western blots demonstrated that there are multiple different antigens recognized. The antibody response was generally higher in MS to all EBV antigens, with particularly significant increases for certain antigens. The investigator’s conclude that the antibody response to EBV in MS is generally increased with altered specificity.


“This is a study that larger confirms what is known in the literature that MSers have a problem dealing with EBV and that there is an abeerrant immune response to the virus. Is this cause or effect; i.e. does EBV cause MS or does MS cause the aberrant antibody response? We don’t know, but the other work on MS suggests that EBV infection is a prerequisite to develop the disease. This is why we are targeting EBV as the most likely virus to cause MS as part  of treatment trials we are planning under the Charcot Project.”

Other post of interest in relation to EBV (please note the research activity into EBV):

15 Sep 2012
The germinal center (GC) model of EBV infection and persistence proposes that EBV gains access to the memory B cell compartment via GC reactions by driving infected cells to differentiate using the virally encoded LMP1 
08 Sep 2012
One of the reasons for thinking this is that if you are EBV seronegative, i.e. you have never been infected with the virus your chances of getting MS are close to zero. The latest meta-analysis we did showed that when you use 
07 Sep 2012
“Evidence of past infection with EBV, in particular infectious mononucleosis or glandular fever, and smoking are well-known risk factors for the development of MS. These two exposures are risk factors for several cancers, 
17 Aug 2012
Objective: Vitamin D deficiency and Epstein-Barr virus (EBV) infection may be associated with the development of MS. We investigated serum 25-hydroxyvitamin D (25-OH-D) levels and anti-EBV immunoreactivity in 25 
01 Jul 2012
BACKGROUND: Epstein-Barr virus (EBV) infection is widely considered to be a risk factor for multiple sclerosis (MS). A previous meta-analysis estimated an odds ratio (OR) for MS in individuals seronegative for EBV of 0.06.
11 Jul 2012
This includes the observation that nearly all MSers show serological (blood) markers of past EBV infection. Given the well-known association between MS prevalence and latitude, we investigated whether EBV seropositivity 
25 May 2012
EBV causes IM I think (the kissing disease) in adolescents and most people would remember having it then, but I don’t think it causes such symptoms in children. Do you know whether anyone who had IM in their teens goes 
25 May 2012
The cause of MS is still unknown but epidemiological and immunological studies have implicated Epstein-Barr virus (EBV), which infects B cells, as a possible aetiological agent involved in disease. Of particular interest is EBV 
04 Apr 2012
To examine the CD8(+) T cell response in greater detail, we analyzed the HLA-A2-, HLA-B7-, and HLA-B8-restricted EBV- and Cytomegalovirus (CMV)-specific CD8(+) T cell responses in MSers and control subjects.
10 Mar 2012
Epstein-Barr virus (EBV) has frequently been investigated as a possible candidate and torque teno virus (TTV) has also been discussed in this context. Nevertheless, mechanistic aspects remain unresolved. We report viral 
03 Feb 2012
Objectives: To identify Epstein-Barr virus (EBV) genotypes and strains in samples from individuals with and without a first diagnosis of central nervous system (CNS) demyelinating disease (a possible precursor to multiple 
15 Jul 2012
The current evidence base supports a strong association between EBV and MS, but potential causality remains strongly debated. Available data on seroprevalence of EBV in MSers has been conflicting and thus used to both 
11 Jul 2012
Here it is proposed that this CD8+ T-cell deficiency underlies the development of chronic autoimmune diseases by impairing CD8+ T-cell control of Epstein-Barr virus (EBV) infection, with the result that EBV-infected 
24 Jul 2011
Results: Higher anti-EBV antibody levels and a history of infectious mononucleosis (IM) were associated with increased CIS risk and there was an additive interaction with the main MS susceptibility gene HLA-DRB1*1501.
01 Feb 2012
Mycobacterium avium subsp. paratuberculosis (MAP; a bacteria or microbe that is related to TB) and Epstein Barr virus DNA were detected in 27.5% and 17.3%, respectively, of the MS patients, compared to 6.3% and 4.5% in 
10 Jan 2012
strangely enough we found many cars parked next to the path and even more strangely we found several white vans (EBV infected white blood (B) cells) – more than you would usually see on a motorway (blood system).
21 Aug 2011
Recent epidemiological and immunological studies provide evidence for an association between Epstein-Barr virus (EBV) infection and multiple sclerosis, suggesting a role of EBV infection in disease induction and disease 
21 Aug 2011
“Hello, in a previous thread you mentioned that in adult MS, EBV is found in 99.9% of cases. This struck me as an amazing statistic, then I googled a bit and read that over 95% of the general population also show evidence of 
24 Dec 2011
OBJECTIVE: To determine whether the activation of innate immune responses, which can be elicited by pathogenic and endogenous triggers, is associated with the presence of Epstein-Barr virus (EBV) infection in the multiple 
19 Jul 2011
They are contrary to what we know about the immune system; if you get infected with one EBV strain your immune system learns and should prevent you getting infected with a second strain. In other words the first EBV strain 
07 Dec 2011
Antibody titers against EBV antigens were measured in serum samples from 222 individuals who developed MS and 444 age, sex, and race/ethnicity matched controls. Conditional logistic regression was used to estimate 
23 Jul 2011
Subjects with raised antibodies in the blood to the EBV protein EBNA1 IgG had a 1.74x higher risk of developing MS. Subjects with antibodies that reacted with the 385-420 fragment of EBNA1 had 3.60x higher risk of 
11 Jul 2011
There is some evidence that EBV reactivation within the body may be triggering MS relapses and disease activity on MRI. Therefore if we can treat MS’ers with a drug that targets EBV we may be able to suppress MS disease 
02 Aug 2011
In this study the researchers have shown that a particular immune cell, called the CD8 T cell, is deficient in MS’ers and contributes to the decreased immune response to EBV-infected B cells. Importantly, this worsens with age 
11 Jul 2011
“This study provides a hint that vitamin D supplementation that results in higher blood vitamin D levels many suppress EBV within the body. Interesting? We think very interesting and trying to work out how EBV and vitamin D 
29 Apr 2011
RESULTS: Children diagnosed with MS were more likely than those with monophasic ADS, i.e. non-MS, to be seropositive for remote EBV infection (37/49 vs 82/185, p<0.001) but not for CMV (7/33 vs 37/97, p=0.09), HSV 
17 Apr 2011
PwMS rarely have antibodies against EBV that are produced within the brain and spinal cord. Some antibodies are produced but are part of the general immune response that occurs in MS. Only rarely are anti-EBV antibodies 
17 Jun 2011
Results of the EBV survey. “Wow, I am surprised. Finally something must be getting through. THANK YOU!!!” Posted by Gavin Giovannoni at 07:13 · Email ThisBlogThis!Share to TwitterShare to Facebook 
07 Jul 2011
Sunlight, Vitamin D and EBV …. More on EBV and MS · Survey results on the issue of woman with MS havin… Article of interest (7) – Infusion reactions to na… Prof DB has a life outside of MS · Symptoms in MS: tremors, 
24 Jan 2010
Even if EBV was proven to be a cause / one of the causes of MS, what would this mean in terms of treatment? Vaccination of children against EBV (when a vaccine is available)? This might erradicate MS for future generations.
04 Mar 2010
A new study looking into the immune response to EBV in people with MS has shown that a group of white blood cells responsible for killing EBV, the so called CD8+ cytotoxic lymphocytes or CTLs, are increased in theblood of 
15 Feb 2012
Here it is proposed that this CD8+ (virus-killing) T-cell deficiency underlies the development of chronic autoimmune diseases by impairing CD8+ T-cell control of Epstein-Barr virus (EBV) infection, with the result that 

3 thoughts on “Antibody response to EBV in MSers is elevated”

    1. as an ms researcher 30 years ago, we measured antibody titers to ebv. technology has improved since then. be patient! they are getting there.

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