Infection with Epstein-Barr virus (EBV) is associated with MS, and MSers have an increased antibody response to some EBV antigens. The major antigens of EBV are only partly defined. The hypothesis that was testes is that the antibody response to EBV is altered in MS. With ELISA, they found that antibodies to EB virions were increased in both serum and CSF of MSers. Western blots demonstrated that there are multiple different antigens recognized. The antibody response was generally higher in MS to all EBV antigens, with particularly significant increases for certain antigens. The investigator’s conclude that the antibody response to EBV in MS is generally increased with altered specificity.