Pregnancy & MS: ECTRIMS Workshop London March 2013

“I am often asked what topics are neglected in MS research, that are very important for MSers? Pregnancy is one of these areas. Therefore it is very appropriate that ECTRIMS has just sponsored a focused workshop on this topic in London. Unfortunately, I did not attend; it was by invitation only. However, Dr Ruth in our group went. I will ask her to do a post on the meeting next week. You may find the programme of interest as well as some of our previous posts on pregnancy.”

Previous posts in relation to MS and pregnancy:

12 Jan 2013
Pregnancy & MS: birth hospitalisation for MSers is no different to anybody else. #MSBlog: For female MSers; MS affect on the outcome of birth for both you and your baby. Epub: Lu et al. On behalf of the British Columbia 
25 Oct 2012
Research: Having a baby? Pregnancy and glatiramer acetate. Epub: Giannini et al. Pregnancy and foetal outcomes after Glatiramer Acetate exposure in patients with multiple sclerosis: a prospective observational multicentric 
14 Aug 2012
Objective: We conducted a longitudinal prospective study to evaluate the long-term effect of pregnancy on the progression of multiple sclerosis (MS). Method: Parous female MS patients were extracted from the database of 
14 Apr 2012
Research: NMO and Pregnancy. Epub ahead of print: Kim W et al. Influence of pregnancy on neuromyelitis optica spectrum disorder.Neurology 2012 Apr 4. OBJECTIVE: To investigate the influence of pregnancy on patients 
16 Jul 2011
“Because of this study, and the fact that pregnancy itself reduces the attack rate, researcher’s have been trying to find out what it is about pregnancy that is so beneficial for MS’ers.” “We assume that the profound changes that 
31 May 2011
Pregnancy and natalizumab: results of an observational study in 35 accidental pregnancies during natalizumab treatment. Hellwig et al. Mult Scler. 2011 May 25. [Epub ahead of print]. Of the women exposed to natalizumab 
28 Jul 2011
Vitamin D intake during pregnancy is associated with a lower risk of MS in offspring. Objective. Vitamin D may have a protective role in the aetiology of MS, but the effect of vitamin D in pregnancy on adult onset MS has not 
15 Jul 2011
Article of interest (6) – Effect of pregnancy on relapses. MS is a common in young women. This study looked at the effect of pregnancy on the course of MS. The relapse rate in each trimester (3 month period) was compared 
16 Sep 2011
Pregnancy outcomes in MS’ers on DMTs. Epub ahead of print: Lu et al. Perinatal outcomes in women with multiple sclerosis exposed to disease-modifying drugs. Mult Scler. 2011 Sep 13. Background: The incidence of 
06 Jan 2013
Data were gathered through a standardized, semi-structured interview, dealing with pregnancy outcomes, breastfeeding, type of delivery (vaginal or caesarean) and epidural analgesia The risk of post-partum relapses and 
05 Jun 2012
BACKGROUND AND OBJECTIVE: Women with multiple sclerosis (MS) who intend to get pregnant are often advised to discontinue disease modifying therapy (DMT) prior to conception. This recommendation is not based on 
20 Dec 2010
Pregnancy and foetal outcomes after interferon-β exposure in multiple sclerosis. A report on 88 pregnancies in Italian woman that were exposed to interferon-beta (average exposure 4 to 5 weeks) has demonstrated that 
15 Nov 2012
This has been hypothesised to be related to maternal vitamin D levels during pregnancy, although conclusive evidence to support this is lacking. To date, no large studies of latitudinal variation in the month of birth effect have 
07 Mar 2013
Mothers of cases and controls were also asked about their smoking exposure during pregnancy. Results: The MS  No association was seen with maternal active or passive smoking exposure during pregnancy. Conclusion: 
27 May 2012
However, these effects were not related to term pregnancy and were fully accounted for by age of MS onset. Conclusions: Pregnancy had no effect on the time to reach an EDSS score 6 (needing a unilateral walking aid; 
19 Sep 2011
Pregnancy rates were 63, 67, 67, and 30% for groups treated with 0, 3, 10, and 30 mg/kg, respectively. The effects observed at  Multiple Sclerosis Research: Pregnancy and natalizumab: results of … Of the women exposed to 
05 Aug 2011
“Why does MS go away during pregnancy?”. Your baby is made up of features from Mum and Dad. The bits from dad should be rejected by the mum’s immune system, just as a organ transplant would be, as they are foreign to 
28 Oct 2012
However, the topic is important and if we want to provide holistic care for woman with MS we need to address how we handle the issue of pregnancy and the advice we give. Misinformation or inconsistent information is one 
13 Jul 2011
The only significant predictor of having a relapse after childbirth was an increased number of relapses in the year before pregnancy and during the pregnancy itself. Therefore, the reported association between breastfeeding 
11 Oct 2012
To investigate if women with multiple sclerosis (MS) experience changes in MS symptoms related to pregnancy, the postpartum period, menopause or use of oral contraception (OC) or postmenopausal hormone therapy (HT).
16 Jul 2012
Results: Among 5949 participants, the majority of respondents (79.1%) did not become pregnant following diagnosis of MS. Of these, 34.5% cited MS-related reasons for this decision. The most common MS-related reasons 
18 Apr 2011
The authors describe the pregnancy and outcome in two women with MS using natalizumab. The first patient  The second patient did not experience MS relapses during pregnancy, while still using natalizumab. Importantly 
03 Nov 2012
In a previous study, we demonstrated that mouse adult F(1) offspring, exposed to a vitamin D deficiency during pregnancy, developed a less severe and delayed Experimental Autoimmune Encephalomyelitis (EAE), when 
30 Apr 2010
Judith Staples and colleagues show that low maternal exposure to ultraviolet radiation in the first trimester of pregnancy is independently associated with subsequent risk of MS in their offspring in Australia. The adjusted 
09 Jul 2012
Predicted UVB radiation and vitamin D status in different time windows during pregnancy were calculated for each month of birth and correlated with risk of ID using the Spearman’s correlation coefficient. RESULTS : The 
25 Dec 2012
CONCLUSIONS: This study confirms previous reports of increased MS births in spring and decreased MS births in the winter months. This could support the role of decreased sunlight exposure during pregnancy and vitamin 
24 Nov 2012
In the very limited material with samples drawn in early pregnancy, where month-of-birth effects were controlled for, we found no association between gestational 25(OH)D levels and MS risk in the offspring. Decreasing 
27 Aug 2012
This is very important as it will underpin strategies for prevention, for example, vD supplementation in pregnancy, and it will provide potential markers to assess the impact of MS preventative strategies in the future. In other 

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