#T4TD menstruation

Women with MS may notice increased fatigue and intermittent symptoms in the second half of their menstrual cycle and during menstruation. Why?

After ovulation, a woman’s body temperature rises by ~0.4℃ (range = 0.3 to 0.6℃) which in someone with MS is enough to cause temperature-dependent conduction block. In addition, the process of menstruation involves a mild systemic inflammatory reaction that may exacerbate fatigue. I refer to this as catamenial fatigue

Catamenial = relating to or associated with menstruation

Over the years I have had several female patients with MS who have reported using aspirin or non-steroidal anti-inflammatories or paracetamol (acetaminophen) to self-manage these two periods of their cycle. Interesting? 

If you suffer from catamenial fatigue you may want to try one of these agents that almost certainly work by lowering body temperature.

#T4TD = Thought for the Day

CoI: none in relation to this post

#T4TD Intermittent diarrhoea?

Did you know constipation with intermittent diarrhoea may mean you have faecal impaction? 

The majority of people with MS who have bowel problems suffer from constipation. This occurs because the MS bowel is sluggish due to reduced motility. This can be made worse by anticholinergic drugs that are used for treating urinary frequency and urgency. Over time pwMS may impact their bowels with faeces, which can form a faecolith (faecal stone). Above the hard and impacted faeces or faecolith, the gut bacteria overgrow and liquefy the stool, which is then able to bypass the impaction and cause diarrhoea. 

So if you suffer from chronic constipation and intermittent diarrhoea you need to contact your HCP for help. 

Please note another cause of this problem is cyclical use of laxatives, i.e. you get constipated and then you use laxatives to treat your constipation. The laxatives then cause diarrhoea so you stop taking them. You then become constipated again and the cycle repeats itself. 

To manage MS-related constipation  you really need to:

  1. Optimise your diet by eating lots of fibre.
  2. Don’t dehydrate yourself. Drink plenty of water and don’t equate caffeine and alcoholic beverages as hydrating. Both caffeine and alcohol cause the kidney to make more urine (diuresis) and are in fact dehydrating.
  3. Try and eliminate concomitant medication that exacerbates constipation (anticholinergics and opioids).
  4. Exercise regularly; the anticipation of exercise and exercise stimulates a defaecation reflex.
  5. If you need to use laxatives start with a prokinetic agent that stimulates the bowel to move, for example, senna, and then add-in bulking (e.g. psyllium husks or other fibre substitutes) followed by liquifying agents (lactulose or polyethylene glycol).
  6. Don’t suppress the need to go to the toilet; a lot of people with chronic constipation have learnt bad habits, for example, they don’t like using toilets that are unfamiliar to them. 

#T4TD = Thought for the Day

CoI: none

#T4TD Feeling tired this morning?

Did you know that as many as 1 in 5 people with MS suffer from obstructive sleep apnoea

Obstructive sleep apnoea occurs when your breathing stops and starts while you sleep. It typically occurs due to a collapse in the tone of the muscles in your throat. The main symptoms of sleep apnoea include making gasping or choking noises while you sleep, snoring loudly, waking unrefreshed with a muggy feeling as if you have a hangover, feeling very tired during the day and frequently falling asleep in the day.

Sleep apnoea is usually treated with a CPAP (continuous positive airway pressure) mask that you wear while you are asleep. Although sleep apnoea is associated with obesity and getting older it can occur in people who are thin with a normal BMI (body mass index). It is very common in MS and is likely to be due to MS lesions affecting the function of the brainstem.

If you identify with any of these symptoms you need to raise the issue with your HCP so that you can be investigated. Sleep studies to diagnose sleep apnoea can even be done at home using portable devices. 

#T4TD = Thought for the Day

CoI: none

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