Using virtually identical ultrasound techniques to try and reproduce the results by Dr Zamboni, Florian Doepp and colleagues in Berlin have not been able to reproduce the results that put CCSVI on the map. Their results seriously challenge the hypothesis that cerebral venous congestion plays a significant role in the pathogenesis of MS.
What are the implications of these findings for people with MS?
Clearly we need to wait for other studies in this area to clarify the discrepency in the results of these studies. From a clinical perspective we continue to advise against undergoing any interventional therapy until there is clarity on whether or not CCSVI is a real entity or not.