New evidence that natalizumab reduces axonal damage

Natalizumab treatment markedly reduces the release of neurofilament into the spinal fluid of people with MS. Neurofilaments are the main structural protein of neurons and axons. This is further evidence that natalizumab treatment reduces the accumulation of nerve injury in MS. Hopefully, this will stimulate pharmaceutical companies to include spinal fluid neurofilament analysis in all of their clinical trials.

Gunnarsson et al. Ann Neurol 2010

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