Epub ahead of print:
Motl et al. Evidence for the different physiological significance of the 6- and 2-minute walk tests in multiple sclerosis. BMC Neurol. 2012 Mar 1;12(1):6.
Motl et al. Evidence for the different physiological significance of the 6- and 2-minute walk tests in multiple sclerosis. BMC Neurol. 2012 Mar 1;12(1):6.
BACKGROUND: Researchers have recently advocated for the 2-minute walk (2MW) as an alternative for the 6-minute walk (6MW) to assess long distance ambulation in MS’ers. This recommendation has not been based on physiological considerations such as the rate of oxygen consumption (V * O2) over the 6MW range.
The term physiology refers to how the body functions normally.
OBJECTIVE: This study examined the pattern of change in V * O2 over the range of the 6MW in a large sample of MS’ers who varied as a function of disability status.
METHODS: 95 MS’ers underwent a neurological examination for generating an Expanded Disability Status Scale (EDSS) score, and then completion of the 6MW protocol while wearing a portable metabolic unit and an accelerometer.
RESULTS:
Oxygen consumption increased significantly every 30 seconds over the first 3 minutes of the 6MW, and then remained stable over the second 3 minutes of the 6MW. This occurred despite no change in cadence across the 6MW (p = .84).
Cadence = speed and rhythm of walking; term often used to describe the movement of a metronome.

“The fact that MS’ers are walking using anaerobic metabolism suggests that they are not very fit or deconditioned. This is not surprising given that you may be disabled and suffer from fatigue. Despite this a graded aerobic exercise programme may help with and improve overall physical functioning and improve mood. Exercise releases endorphins into the brain that elevate your mood and make you feel good.”
“How many of you exercise regularly?”
I believe that all MS'ers should be given access to a physio/personal trainer who can help put together personalised exercise plans. I am very active and plan to continue being so for as long as I can. I just wish there was more help available in terms of specialist advice re. managing exercise and fatigue, building core muscles etc. The physios at the MS Therapy Centres are generally fantastic but it means you're reliant on having a centre near by.
I walk with crutches yet I'm at the gym 3 times a week doing weights and cardio. I do physio excercises for 20 minutes everyday too.I am a fitness freak, but I was like this even before developing MS. It's all down to lifestyle, ability and need.