Research: natalizumab may reduce cognitive changes and brain atrophy Tysabri may reduce cognitive changes in RRMS

Epub: Portaccio et al. Natalizumab may reduce cognitive changes and brain atrophy rate in relapsing-remitting multiple sclerosis: a prospective, non-randomized pilot study. Eur J Neurol. 2012 Oct 11. doi: 10.1111/j.1468-1331.2012.03882.x.

BACKGROUND AND PURPOSE: The development of treatment strategies for cognitive impairment in MS is still in its infancy. The objective of this prospective, non-randomized, pilot study was to assess the possible efficacy of treatment with natalizumab in comparison with interferon beta (IFNB) in a group of RRMSers.

METHODS: We included 12 MSers treated with natalizumab and 14 with IFNB. At baseline and at follow-up, cognitive functioning was assessed through the Rao’s Brief Repeatable Battery. All the MSers underwent brain MR study with the assessment of T2 lesion volumes (T2LV), neocortical volume (NCV), normalized brain volume (NBV) and percentage brain volume change (PBVC). Evolution of cognitive performance was assessed using available normative data for the Italian population. Treatment comparisons were assessed through the Mann-Whitney U-test, anova for repeated measures and linear multivariate regression analyses.

RESULTS: After a mean follow-up of 1.5 years, the mean number of neuropsychological tests with a deteriorating performance was significantly lower in MSers treated with natalizumab (0.7 ± 0.7 vs. 1.7 ± 1.4; P = 0.031). Likewise, PBVC was significantly lower in natalizumab-treated MSers than that observed in MSers treated with IFNB (-0.51 ± 0.47% vs. -1.18 ± 0.98%; P = 0.050).

CONCLUSION: The results suggest a potential beneficial effect of natalizumab therapy on cognitive functioning in MS, possibly mediated by a reduction of brain atrophy.

“This study is too small to draw any conclusions from, but suggests Nz is more effective than IFNBeta when it comes to preserving cognition. Are you surprised?”

“My new moto – protect your brain, it is easier to prevent than repair damage!”

CoI: multiple

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