“There are many reasons why MS may be more common in females than males. The following epidemiological study suggests high testosterone levels in males may protect you from getting MS. How? To be honest I haven’t a clue. What this study shows that men with testicular hypofunction have a much greater risk of developing MS than normal males. This observation will need to be explained when we finally pin down the cause of MS. I sincerely hope that countries such as Sweden and Denmark, with national databases, try and reproduce this observation; it may be a lot more important than we realise.”
Epub: Pakpoor et al. Testicular hypofunction and multiple sclerosis risk: A record-linkage study. Ann Neurol. 2014 Aug 18. doi: 10.1002/ana.24250.
Background: The influence of gonadal hormones on multiple sclerosis is not well characterised and has thus far been investigated primarily in animal models or as a proposed therapeutic approach.