Magalhaes et al. The EnvIMS Study: Design and Methodology of an International Case-Control Study of Environmental Risk Factors in Multiple Sclerosis. Neuroepidemiology. 2015 May 7;44(3):173-181
BACKGROUND: MS is a chronic disease of the central nervous system, often resulting in significant neurological disability. The causes of MS are not known; however, the incidence of MS is increasing, thereby suggesting that changes in lifestyle and/or environmental factors may be responsible. On this background, the Environmental Risk Factors in MS Study or EnvIMS study was designed to further explore the etiology of MS. The design and methodology are described, providing details to enable investigators to (i) use our experiences to design their own studies; (ii) take advantage of, and build on the methodological work completed for, the EnvIMS study; (iii) become aware of this data source that is available for use by the research community.
METHODS: EnvIMS is a multinational case-control study, enrolling 2,800 cases with MS and 5,012 population-based controls in Canada, Italy, Norway, Serbia and Sweden. The study was designed to investigate the most commonly implicated risk factors for MS etiology using a self-report questionnaire.
RESULTS/CONCLUSIONS: The use of a common methodology to study MS etiology across several countries enhances the comparability of results in different geographic regions and research settings, reduces the resources required for study design and enhances the opportunity for data harmonization.
2 thoughts on “EnvIMS Risking MS”
This type of study will enable even determine which environmental factors are acting in a given population, the variability of these factors country to country between ethnic groups, etc. Surely there must be differences related to environmental factors that cause MS in populations in the UK of which cause MS in populations of South America, for example. Or not, can come to the conclusion that there is no difference … Pretty cool same focus also in this light that is not purely genetic …
When is your consortium study starting?